Your daily dose of health.

Give your body what it really needs to stay healthier and feel better—from head to toe. Plexus® XFactor Plus is a multivitamin that does just that - with premium, bioavailable forms of key nutrients, a high-potency B vitamin complex, and a gut-protecting polyphenol blend. It's the multivitamin - redefined.*

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  • Supports immune function*

  • Supports healthy bones and muscle function*

  • Helps support healthy blood pressure levels already

  • in the normal range*

  • Protects against free radical damage*

  • Supports energy-yielding metabolism*

  • Promotes mental clarity*

  • Supports thyroid function*

  • Supports eye health and night vision*

  • Promotes normal cognitive function*

  • Can help with symptoms of menopause including hot

  • flashes and occasional sleeplessness*

  • Helps to brighten the skin, and maintain healthy

  • collagen levels*

We live in an age of medical breakthroughs, but it seems that we are not getting any healthier. Fast food sales have increased 2000% since 1981. Only 10% of Americans eat the daily recommendation of fruits and vegetables, and produce is not as nutritious as it should be. We are overfed and undernourished—XFactor Plus can help.1,2

Over ½ of Americans take a multi every day, but there are SO many multi’s to choose from. How do you know which ones truly work? How do you know that your multi is giving your body the nutrients it needs? The truth is that many multivitamin formulas on the market today use cheap forms that are not bioavailable—meaning they can’t be used by the body. Many multi’s also contain binders, lubricants, and coatings, adding to the absorption issue and putting unwanted substances into your body.6

It’s time for a multivitamin that gives your body the nutrients it really needs.

XFactor Plus is recommended for both men and women interested in improving their overall health and wellness by filling their “nutrient gap” with a high quality, highly bioavailable, complete multivitamin that also provided additional benefits to your gut.◊*


  • Over 90% of the population has inadequate intakes of vitamin D and vitamin E. Vitamin D plays an important function in promoting bone density and vitamin E is essential in promoting cardiovascular health.*3,4

  • B vitamins are essential to your health, affecting everything from your metabolism, to your nervous system, to your energy level, to your mood.

  • Approximately 40% of the U.S. population carries the gene mutation that prevents them from being able to convert folate into its active, usable (or methylated) form 5-MTHF. Folate is essential for cell replication and growth assisting in the normal utilization of amino acids and proteins, as well assupporting formation of building block of DNA and RNA.*5

  • Vitamin D3, found in XFactor Plus, is the naturally occurring form of vitamin D in the body, and is therefore more bioavailable than the more commonly used vitamin D2.


  • Delivers highly bioactive and bioavailable forms of key ingredients for superior absorption

  • Contains 100% or more of the daily value of 19 vitamins and minerals

  • Contains a high potency, complete B Vitamin complex

  • Features polyphenols to help protect your gut microbiome*

  • Contains naturally occurring trace minerals

  • Contains no binders that can slow absorption

  • Non-GMO

  • Vegetarian

  • Gluten free

Plexus XFactor Plus™ takes multi to the next level. Our scientists searched high and low to find premium forms of the best ingredients, to help you stay healthier and feel better—from head to toe.*
XFactor Plus gives you a complete multivitamin for overall health and wellness, with at least 100% daily value of 19 essential vitamins and minerals, including a high-potency B vitamin complex. It also features over 50 naturally occurring trace minerals; these trace minerals are sustainably sourced from all-natural, marine-based material, which are derived from the clean waters off the Irish coast. But that isn’t all that sets XFactor Plus apart. XFactor Plus is formulated with the most bioactive and bioavailable forms of key nutrients, many of which are often neglected by competitors in the market.*

Among these nutrients is methylated folate (5-MTHF). Although other supplements contain standard forms of folate or folic acid, these common forms must go through a complicated metabolic process before your body can use them. Methylated folate bypasses this process, giving you an already active form of folate that your body can utilize and benefit from. Methylated vitamin B12 is also included, which, unlike other forms of B12, is tissue-ready and easily processed by the liver, so your body can use it right away. XFactor Plus also contains vitamins K1 and K2. K2 is particularly difficult to find in foods or other supplements, but as the most bioavailable form of vitamin K, it is crucial to your health, playing a critical role in cardiovascular and bone health.*

XFactor Plus also uses several minerals in their most bio-available forms. Many of these minerals, such as molybdenum and boron, are chelated. Chelated minerals have complex structures that allow the minerals to travel freely in the digestion process into the small intestine, where they can be effectively absorbed into the bloodstream. This maximizes the benefit that these minerals give to you and your health.*

XFactor Plus features our Microbiome Activating Complex. This revolutionary formula delivers up to 400 milligrams of powerful polyphenols, like apple and grape seed extract, that work to protect your gut microbiome and help it thrive. Grape seed extract acts as a powerful antioxidant and offers excellent cardiovascular support. Grape seed extract has also been shown in a clinical study to help with symptoms of menopause by helping reduce hot flashes, and feelings of anxiety, and helps with those who have difficulty sleeping.◊*

The Microbiome Activating Complex in XFactor Plus has been tested in an independent, highly advanced in vitro study that simulates the human gastrointestinal tract. Preliminary findings indicate:


  • Reduced production of undesirable compounds in the gut◊*

  • Reduced ammonium levels in the gut by 18%◊*

  • Increased beneficial lactobacillus by 15x◊*

  • Increased beneficial Akkermansia microbe by 9x◊*

  • Increased beneficial bifidobacterium by 2x◊*

All this, without binders, gluten, common allergens, or GMOs.

Leave your old multi behind. Get your daily dose of health, every day, with XFactor Plus.



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*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.




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*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.


◊ The results of an in vitro human gut simulator study suggest that the polyphenol blend in XFactor Plus may have several beneficial effects.Further research, including research conducted in humans, is needed to confirm these preliminary findings.


3 Fulgoni VL, Keast DR, Bailey RL, Dwyer J. Foods, fortificants,and supplements: where do Americans get their nutrients? JNutr 2011;141:1847–54.
4 Wallace TC1, McBurney M, Fulgoni VL 3rd. Multivitamin/mineral supplement contribution to micronutrient intakes inthe United States, 2007-2010. J Am Coll Nutr. 2014;33(2):94-102.